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FKBP12-targeting-PROTAC

FK506 binding proteins (FKBPs), also known as tacrolimus, are a family of immunophilins ubiquitously widely existing in eukaryotic organisms such as humans, plants, animals and yeast. As a cytosolic FKBP, FK506-binding protein 12 (FKBP12, or FKBP1A) is the smallest member and the most researched one among the identified mammalian FKBPs, which was named for its molecular weight of 12 kDa. Early in 1989, FKBP12 was characterized as the target or receptor of the immunosuppressive drug FK506 and Rapamycin, of which both molecules were noncovalently bound to FKBP12 to inhibit its PPIase activity. FKBP12-targeting-PROTAC https://www.creative-biolabs.com/protac/ligand-design-for-FKBP12-targeting-protac.htm

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